Dear Editor,
We congratulate Aksoy et al.1 for their study entitled “Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus”. We have read the article with interest. They evaluated and compared the topographic data and corneal higher order aberrations of fellow eyes of unilateral keratoconus patients with keratoconic eyes and control group. They retrospectively reviewed the medical records of 392 eyes of 196 patients with keratoconus and identified 20 patients (%11.2) with unilateral keratoconus. The diagnosis of unilateral keratoconus was defined as having a keratometric astigmatism below 1.5 diopter (D), vertical keratometry (K) value below 47.0 D, and no keratoconus patterns on corneal topography in this study. The results of the study revealed that there is no statistical difference in best corrected visual acuity between fellow eyes and control, whereas K1, K2, and cylindrical power values were significantly higher in the fellow eyes. Comparison of quantitative topographic indices showed that all indices except the inferior-superior ratio are significantly higher in the fellow eyes in keratoconic patients than in the control group (p<0.05). We express our gratitude to the authors regarding this study. However, we want to specify some matters and our thoughts related to this article.
First, we would like to emphasize that the term of ‘unilateral keratoconus’ is not appropriate. Because, according to the global consensus on keratoconus and ectatic diseases, keratoconus is a bilateral corneal disease.2 However, clinical and topographical findings of the disease may not be evident one of the eyes. Many different terms such as subclinical keratoconus, keratoconus suspect, and forme fruste keratoconus have been employed to describe the preclinical stages of keratoconus.3 We think that the term of “unilateral keratoconus” in this study may be confused with “subclinical keratoconus”. Additionally we believe that posterior corneal elevation and pachymetric index are more sensitive index for the early diagnosis of keratoconus. Hence, the patients in the study must be evaluated by using these analyses. The studies by us4 and Bae et al.5 revealed that even these analyses are not adequate to detect the subclinical keratoconus. We examined the medical records of 3474 patients with keratoconus and 116 (3.3%) cases with subclinical keratoconus were detected. The diagnosis of subclinical keratoconus was defined as having a central mean K value less than 47.2 D, an inferior-superior asymmetry for the average K less than 1.4 D, a keratoconus percentage index (KISA%) of less than 60%, and no clinical evidence. After that, these patients were analyzed with the Belin-Ambrósio Enhanced Ectasia Display (BAD) III, which evaluates the pachymetric progression and anterior and posterior elevation values of the cornea. Normal BAD analysis were detected in only 38 (1.1%) of these patients. We found that there were no statistically significant differences between the eyes with subclinical keratoconus who had normal BAD analysis and the controls in visual acuity, topographic, topometric and tomographic parameters (for all, p>0.05). We only detected statistically significant differences with regard to corneal densitometry values. Accordingly, we think that if the authors would take into account the posterior corneal surface and pachymetric indices, the prevalence of subclinical keratoconus in their study may be reduced and the keratometry values as well as some of the topographic parameters and surface index parameters might not be statistically significantly different between the fellow eyes and normal eyes.
Ethic
Peer-review: Externally and internally peer-reviewed.
Authorship Contributions
Concept: Mustafa Koç, Kemal Tekin, Design: Mustafa Koç, Kemal Tekin, Data Collection or Processing: Mustafa Koç, Kemal Tekin, Analysis or Interpretation: Mustafa Koç, Kemal Tekin, Literature Search: Mustafa Koç, Kemal Tekin, Writing: Mustafa Koç, Kemal Tekin.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study received no financial support.
Response from the Authors
Dear Editor,
In a Letter to the Editor written in response to our article entitled “Topography and Higher Order Corneal Aberrations of the Fellow eye in Unilateral Keratoconus” published in the Turkish Journal of Ophthalmology issue 2017/5 (reference no: TJO-45220), the author claimed that the term “unilateral keratoconus” is inappropriate, and that the term ‘subclinical keratoconus’ should be used instead. The author stated that posterior elevation and pachymetry data are more sensitive indexes in the detection of subclinical keratoconus, and the use of these data would reduce the rate of subclinical keratoconus in our study.
The term unilateral keratoconus is used in the literature. These publications were also cited in our article. We stated that the eyes considered topographically and clinically normal in unilateral cases may eventually develop signs of keratoconus findings if followed long enough. The NIDEK Magellan Mapper, which is available in our clinic and was used in our study, is a Placido-based system that only provides data regarding the anterior cornea surface. The lack of posterior corneal surface data was given as one of the limitations of our study. The points criticized by the author have already been addressed in our article, as shown below:
Introduction, paragraph 2: “The progressive course of the disease ultimately affects both eyes, though only one eye may be affected initially. The prevalence of true unilateral keratoconus has been reported to range from 0.5-4% in studies using computerized videokeratography1,2 and was 4.5% in a more recent study using slit scanning corneal topography (Orbscan 2).3 Holland2 reported that patients with unilateral keratoconus developed keratoconus symptoms in their apparently healthy fellow eyes 4 years later, while Li et al.4 found that keratoconus developed in 50% of cases within 16 years. Therefore, it may be concluded that the fellow eyes of patients with unilateral keratoconus may seem normal with regard to clinical and topographical pattern but have subclinical keratoconus.”
Discussion, last paragraph: “In our study, the unilateral keratoconus ratio was found to be 11.2%. The prevalence of true unilateral keratoconus is reported in the international literature as ranging between 0.5% and 4.5%. In a study conducted in Turkey, a unilateral keratoconus prevalence of 14.9% was determined using Pentacam.5 The main limitation of our study was that the elevation data provided by our topography device was not adequate and not able to evaluate the posterior corneal surface. Another limitation is that long-term patient follow-up data was not available. The suspected keratoconus eyes that we determined to be normal may exhibit signs that would lead to a keratoconus diagnosis if examined using more advanced topography systems.”
Best Regards,
Sibel Aksoy, Sezen Akkaya, Yelda Özkurt, Sevda Kurna, Banu Açıkalın, Tomris Şengör
